Ventskivskyy K. Prevention of gestational and puerperal complications in pregnant women with HIV- herpes associated infection.

The work is devoted to the decreasing the frequency of complications of pregnancy, delivery and the postpartum period in pregnant women with HIV- associated herpes infection by assigning additionally to antiretroviral therapy an immunomodulating drug of herbal origin. Several common complications, appropriated to pregnancy by HIV- associated herpes infection are found, such as high frequency threat of abortion in the first half, pterterm labour activity after 22 weeks, unspecific infectious complications , anemia. Some characteristic features are obtained by investigation of humoral immunity - in pregnant women with HIV- associated herpes infections classes proinflammatory cytokines are dominating, indicating activation of the immune system with simultaneous decrease of their anti-inflammatory forms. The changes in the cellular immune system - typical HIV -positive reduction in CD4/CD8 ratio in a group of pregnant women with HIV- associated herpes infection is more pronounced , indicating a deeper disorder of immune regulation. According to more profound disorders in the immune system is exposed pregnant women with HIV- associated herpes infection, a positive impact on the gestational process immunostimulatory drugs of herbal origin is considered. In pregnant women with a combined HIV- HSV infection, that received in addition to standard antiretroviral therapy an immunostimulating drug gestation complications such as anemia, preterm labour activity, unspecified inflammatory disease were less likely registered than among patients who received only antiretroviral drugs. In addition, comprehensive treatment can reduce the incidence of preterm birth, abdominal delivery because of a viral load above 1000 copies