Malakhov P. Characterization of rotavirus infection epidemic process at the present stage and improvement of the epidemiological surveillance measures (on the model of Odessa Region)

The thesis investigates the peculiarities of the epidemic process of rotavirus infection (RVI) in Odessa region for the period of 1998-2011, which was manifested by sporadic morbidity and outbreaks. It is shown that the proportion of RVI cases in the structure of acute gastroenterocolitises by established aetiology is 4,97%. Persons suffering from RVI are encountered in all age groups, but the proportion of children up to 3 years old is 72,82%, they are classified as being at group of risk. With increasing age the incidence of RVI is reduced. The incidence of RVI tends to increase, differs by intervals of 3-4 year cycle of increase and winter - spring seasonality. The annual incidence of RVI dynamics is associated with the activation of contact - household transmission in the cold season and water - in the spring and summer. Rotaviruses are permanently isolated from the drinking water during the period under study. Activation of the RVI epidemic process was accompanied by increase in the number of positive samples of the drinking, sea water and sewage. Rotaviruses of the group A of four P[G] genotypes are circulating in Odessa region now. During 2009-2010 there was a change of the dominant genotype P[8]G1 for P[8]G3, which circulates throughout the year, supporting the average seasonal incidence level.