Pinchukova N. Technology principles of cocarboxylase hydrochloride production with the use of microwave irradiation.

The object of the research was production of cocarboxylase hydrochloride (CCHC), namely the stages connected with heating and product isolation. The scope of the research was development of scientific principles of energy efficient technology of CCHC production with the use of microwave irradiation as an alternative source of processes activation. The experiments were carried out with the use of dedicated microwave equipment, both home-made and of renowned world manufacturers (CEM Corp (USA), Biotage (Belgium)). Vast variety of analyses were used in the work, such as high performance liquid chromatography, gas chromatography, volumetric and weight analyses, X-Ray diffraction studies, mass-spectrometry, optical microscopy, thermometry, thermography. The influence of microwave irradiation on the orthophosphoric acid dehydration, thiamine phosphorylation, evaporation of cocarboxylase aqueous solutions, and CCHC drying was first studied. Hypotheses have been proposed explaining non-thermal character of microwave processes acceleration. The controlled crystallization procedure comprising microwave-assisted evaporation of solutions was first developed, which resulted in significant reduction of CCHC drying time. Based on the appropriate calculations, the efficient scaling up of all the studied processes was shown to be feasible. Energy efficiency and process times' reduction resulting from substitution of thermal heating sources for microwave irradiation were estimated. The principal schemes of microwave production equipment were proposed. Production technology for microwave drying of CCHC was developed and introduced. The results of the thesis are used in the study course at chemical department of Kharkov National University named after V.N. Karazin.