Lekishvili S. Optimal treatment for diabetic retinopathy with help of natural antioxidant complex (experimental and clinical research)

The thesis is devoted to the optimization of the treatment of diabetic retinopathy using a set of natural antioxidants. The use of antioxidant complex " Kratal + Vitamin C " in rats with streptozotocin diabetes in high-6 weeks inhibits the development of basal hyperglycemia and non-enzymatic protein glycosylation process, reduces the intensity of lipid peroxidation inhibition nitrozivnogo stress and restores the antioxidant defense system in the blood of experrmental animals. Essenntially inhibits lipid peroxidation and restores the glutathione-dependent antioxidant component in homogenates of rat retina with high-streptozotocin diabetes. Reduces the build-up polyol path - sorbitol in retinal homogenates. Complex of natural antioxidants has a positive effect on glycemic control and the initial reaction of non-enzymatic glycosylation in patients with nonproliferative diabetic retinopathy, is confirmed by the reduction of basal and postprandial hyperglycemia and fructosamine concentrations in serum, oxidative stress is also reduced in patients with type 2 diabetes due to inhibition of peroxidation lipids and activation of superoxide dismutase - an enzyme anti-radical protection. It increases functional parameters of the vision of patients with type 2 diabetes with nonproliferative diabetic retinopathy. Revealed corrective influence of natural antioxidants combination "Kratal + Vitamin C "in the methabolic an the functional status of the organ of vision in patient with type 2 diabetis demonstrates its long - range application in order to reduse the progression of nonproliferative diabetic retinopathy. This method of treatment is introduced into clinical practice.