Amosova A. Role of polymorphic genes’ variants controlling the system of hemostasis in its malfunction at tuberculous process

The scientific research concerns pathogenetic features of hemostatic disorders in patients with tuberculosis on the background of gene polymorphisms SERPINE1, 4G/5G and F13A1, Val/Leu. Analysis of medical records, biochemical studies of blood plasma, biophysical method of low-frequency vibration piezoelectric hemocoahulohraphy, studies of the macromolecular composition of blood plasma by laser correlation spectroscopy and molecular-genetic studies of gene polymorphism of system of hemostasis in patients with tuberculosis were made. It was found that patients in the dynamics of the tuberculous process revealed coagulation activation and inhibition of the fibrinolytic system. Changes in the hemostatic system are connected with a positive bacteriological study, the absence of destructive processes in lungs and the resistance of mycobacteria to antituberculosis drugs. It is shown that patients with above mentioned hemostatic disorders have increased level of light scattering particles contribution with a hydrodynamic radius from 12 to 38 nm. Analysis of polymorphic genes prevalence SERPINE1, 4G/5G and F13A1, Val/Leu showed no association with increased risk of tuberculosis. The association of gene polymorphism with age, positive result of bacteriological studies, type of case of tuberculosis and the absence of destructive processes in the lungs was revealed. There was also significant contribution of gene polymorphisms in changes of some hemostatic indexes level.