Gladun K. Clinical features and neuroendocrinal mechanisms of forming of arterial hypertension in children with obesity

The thesis is devoted to the improvement of measures directed on the prophylaxis of origin of arterial hypertension in children with obesity on the basis of researched motional features of disease and mechanisms of development of arterial hypertension. On the basis of children's complex inspection, patients with obesity is singled out the motion of obesity in 34,5% of children is complicated by the development of arterial hypertension. The factors of risk of development of arterial hypertension is the heredity of birth accompanied by the obesity due to pregnancy happening with the threat of breaking, early artificial child's feeding, being allergic to food, hyperinsulinemia and insulinoresistence. Forming of AH is accompanied by the exhaustion of both links of VNS with the maintenance of relative sympathy and changes of terminable and spectral indexes. The development of arterial hypertension in children and patients with obesity hasppening in the conditions of growth of endocrine activity of visceral adipose tissue and development of disbalance of synthesis of adipokines is proved. The determined changes in children with obesity are accompanied by hyperaldosteronism, hypercortisolemia phenomena and the development of endothelial disfunction. The prognostic matrix of risk of origin of AH in children with obesity is designed. It is pointed out the additional application in the complex of therapeutic measures of anorexigen medication of central action assisting to the effective mass body reducing, potential arterial hypertension decreasing and normalization of endothelial function