Jemela O. Pathogenesis features of morphological and functional properties of red blood cells in rats of different age groups in hypoxia

Dissertation is devoted to the study of pathogenetic features of morphological and functional properties of red blood cells in rats of different age groups during hypoxia. It is proved that in the peripheral blood of rats of different ages during hypoxia contained erythrocytes with different deformability. Changes in the number of red blood cells, hemoglobin and red blood cell indices in hypoxia caused membrannodestruktivnymi processes in red blood cells, reducing their absolute numbers due to hemolysis, as well as changes in hematocrit due to redistribution of blood. The deformation of erythrocytes in conditions of hypoxia hemic varies depending on the age of the animals: the maximum deformation ability of erythrocytes observed in the prepubertal period, rats (40,2 %) and the minimum - in the group of old rats (19,7 %). Age-related changes in the membranes of red blood cells in hemic hypoxia were to increase the viscosity of the lipid bilayer (index microviscos decreased in aged rats compared to young adult animals of 69,5 %) and the percentage increase in skeletal proteins (spectrinum by 53,0 %), which determines the reduction erythrocyte deformation. Simultaneous reduction of the protein fractions with a relatively low molecular weight, localized at the inner side of the membrane of erythrocytes may be one of the causes of the structural and functional changes in age membranes of red blood cells. In old animals, changes occur more clearly and durable.