Raskina K. Improvement of treatment and prevention approaches in children with mild persistent bronchial asthma

This thesis is dedicated to improving of mild persistent bronchial asthma early diagnosis in children, increasing effectiveness of treatment and prevention measurements on the ground of investigations of the prevalence, clinical, pathogenetic, immunological and functional parameters and development the differentiated program of asthma anti-inflammatory therapy. The most important risk factors for asthma exacerbations were ARVI, pollen and meteosensitivity. Isolated virusinduced asthma phenotype was detected in 16,7% of children who had negative results of skin tests. It was proved that school maturity in children with bronchial asthma according to Kern-Iyersek's test has moderate level (7,4±0,3 balls) and depends on control level by Asthma Control Test. Variety of inflammatory activity in 6-7 years old children with firstly mild persistent asthma diagnosis was shown, which needs differential treatment algorithms: basic therapy selection and its duration. Practicability of leukotriens (C4/D4/E4) and sICAM-1 levels evaluation before treatment for choosing the appropriate anti-inflammatory therapy was established