Derkach Z. Clinical and prognostic significance of lipid metabolism parameters and general nonspecific adaptive responses in patients with chronic kidney disease combined with obesity

The object of study - chronic kidney disease, obesity.The purpose of the study - study the characteristics of the stages of CKD, establish criteria for its adverse flow based on determining the features of lipid metabolism and adaptation processes in patients with overweight and obesity. For CKD in patients with excessive body weight heavier than normal weight, as much more frequently accompanied by hypertension, anemia, inflammatory syndrome, adverse reactions adaptation distress. Overweight is a risk factor for progression of CKD and of premature cardiovascular events. Obesity is accompanied by hypertriglyceridemia, which is a risk factor for progression to end-stage CKD and the need for renal replacement therapy. CKD at 88.8% followed by dyslipidaemias. High (more 6.2 mmol / l) and low (smaller 4.6 mmol / L) blood cholesterol levels decreased survival. Elevated levels (more 1.7 mmol / L) blood triglycerides performed risk factor of progression of CKD and significantly reduced survival of patients with CKD. CKD provided adverse adaptive reactions of distress were observed in 34.6% of patients, significantly more commonly associated with hypertension, anemia, proteinuria, dyslipidemia. Distress is a risk factor for progression of renal failure and cardiovascular complications. Defined factors increased risk of death in patients, the risk of cardiovascular complications (myocardial infarction and acute stroke), progression of CKD to end-stage. Industry - medicine.