Kadzharyan E. The functional state of corticotrophinergic and beta-endorphinergic systems of rats' hypothalamus with streptozotocin-induced diabetes under the influence of hypoxic trainings

As a result of a comprehensive study of the neurons of the medial parvocellular subnucleus of hypothalamus paraventricular nucleus with sophisticated morphometric, densitometric and immunofluorescence techniques the distribution features and morphometric characteristics of hypothalamic neurons that synthesize corticotrophin-releasing hormone and beta -endorphin were first installed. The first time the regulating effect of hypoxic trainings in rats with diabetes on the state of corticotrophinergic and beta-endorfphinergic systems of medial parvocellular subnucleus of hypothalamus paraventricular nucleus that characterized by the decrease of immunoreactivity area, the concentration of neuropeptides and their total content in subnuclei. For the first time was demonstrated that the degree of reduction in the functional activity of stress- limiting beta-endorphinergic system of paraventricular nucleus of rats with diabetes mellitus after hypoxic training are less pronounced than the decrease in activity of stress- realizing corticotrophinergic system. Established new mechanisms that explain the sanogenic effect of intermittent hypoxia in experimental diabetes by restoring balance between the corticotrophinergic and beta-endorphinergic systems of hypothalamus . The calculated rate of the balance between the stressrealizing and stresslimiting systems of the hypothalamus as the characteristics of the system as a whole in a negative impact on the body.