Chornopyska Y. Peculiarities of preparation and conduct of assisted reproductive technology cycles in infertile women with excess body weight

The research paper deals with increasing the frequency of pregnancies by developing and introducing an algorithm of diagnostic, treatment and preventive measures using an optimized program for controlled ovarian stimulation in women with anovulatory infertility and excess body weight. The paper provides a deeper insight into the role of excess body weight in the development of reproductive disorders. It dwells on the comparative aspects of endocrine and ovarian disorders in infertile women with excess body weight. The paper discusses new aspects of infertility pathogenesis in women with excess body weight, i.e., reproductive disorders are discussed based on the studied interconnection between the clinical, functional, endocrine, immunological and biochemical parameters, which enabled assessment of the reproductive system's capability for fertilization, optimization of pre-gravid preparation to controlled ovarian stimulation, as well as an increase in the overall efficiency of the treatment and preventive complex while reducing the economic load on the patient. The results obtained provided a scientific rationale for the need to improve the current diagnostic and ovarian stimulation regimens in women with anovulatory infertility and excess body weight. The author suggests altering the approach to the diagnostic steps and management of patients with anovulatory infertility and excess body weight towards an active adapted and comprehensive diagnostic and therapeutic preparation to controlled ovarian stimulation. The paper proves the efficiency of the developed comprehensive preparation to controlled ovarian stimulation following a detailed analysis and forecasting of the likely results, taking into consideration the endocrine and lipid metabolism aspects. The above approach resulted in an increased frequency of pregnancies with a reduced economic load on the patients with anovulatory infertility and excess body weight.