Rozheliuk I. Effect of drugs on neurotransmitter mechanism of clinical-neuropsychological and neurophysiological parameters in elderly patients with cognitive disorders of alzheimer's and vascular genesis.

The dissertation is focused on the study of the peculiarities of the mechanism of action of drugs on neurotransmitter clinical-neuropsychological and neurophysiological parameters in elderly patients with cognitive disorders, depending on the stage, origin of the disease and ApoE gene polymorphism. The efficiency of a standardized extract of Ginkgo biloba was proven in all subtypes of the syndrome MCI. It is advisable to use pirybedyl at non-amnestic subtypes MCI. A comparative analysis of the effectiveness of donepezil hydrochloride and memantine in the elderly patients with AD have shown positive effects memantine in a wider range of cognitive domains. In the treatment of vascular dementia - differences in efficacy observed a positive impact of donepezil hydrochloride on performance orientation in time and space. It has been proved that the presence of allele 4 ApoE is associated with a greater degree of cognitive decline according to the MMSE total score scale. There was established a significant prevalence of individuals with genotype e4/e4 among patients with AD compared with patients with vascular dementia (respectively, 24% and 4%). The effectiveness of the treatment of cognitive impairment in dementia donepezil hydrochloride and memantine might be higlhy correlated with ApoE gene polymorphism.