Berezovska I. Method and system of photodynamic therapy on the basis on semiconductor quantum-dimension structures

Object of research - the generation of singlet oxygen in biological media with semiconductor quantum-dimension structures in the process of photodynamic therapy. The purpose of research - development of a method and system for photodynamic therapy using quantum- dimension structures - semiconductor quantum dots as photosensitizers for photodynamic effect. Methods of research - theoretical research work based on mathematical modeling of photodynamic processes PDT using quantum dots by using certified software packages. Experiments were conducted using proven optical and electrochemical methods, techniques and equipment. The developed system of photodynamic therapy using semiconductor quantum dots. This system allows the selection of quantum dots with the corresponding absorption band absorption band, the most suitable for the selected light source and the location area of the tumor disease. Scientific novelty - improved method of photodynamic therapy by using quantum-dimensional structures such as quantum dots (CdTe/TGA), which allows significantly improved by increasing the yield of singlet oxygen as the main active element PDT; first developed a mathematical model of the kinetics of the generation of singlet oxygen in biological media with quantum dots (CdTe/TGA), taking into account the kinetics of its interaction with histidine as "chemical trap", which allowed a theoretical basis and noted the effective use of quantum dots CdTe/TGA as a photosensitizer in PDT method; first using the "chemical traps" experimentally proven to generate singlet oxygen in a model system with quantum dots (CdTe/TGA) for PDT and the main parameters of the process that allowed us to estimate the efficiency of the generation of singlet oxygen in photodynamic process. Implementation - in " Grigorjev institute for Medical Radiology of NAMS of Ukraine".