Opanasenko H. Stress-induced disorders of the oxygen transport and oxygen-dependent processes in periodontal tissues and their pharmacological correction.

The work is dedicated to the investigation of the oxygen dependent mechanisms of stress-induced damage in rat periodontal tissues and the possibilities of applying Actovegin and Thiotriazolin for the prevention and correction of violations in transport and utilization of oxygen in these tissues during prolonged immobilization stress . A study of the influence of immobilization stress both on the bone tissue of the alveolar processus of jaws and soft periodontal tissues has revealed the presence of severe degradation of the dental alveoli lands and significant structural changes in the biological barriers. Analysis of the oxygen supply of periodontal tissues in the development of stress reaction allowed to state a decrease in oxygen tension in rat gums and a sharp decrease in oxygen consumption by bone tissue, which can greatly associate with a reduction in blood oxygen transport to tissues due to a decrease in the blood flow volume velocity. These results evidenced for the development of periodontal tissue hypoxia during prolonged immobilization. Under immobilization stress, there was found the violations of the efficiency of oxidative phosphorylation, the prooxidant-antioxidant balance and the intensity of mitochondrial biogenesis in the periodontal tissues.It was shown that the using of pharmacological agents such as metabolite intended Thiotriazolin and Actovegin under prolonged immobilization stress reduces this stress-induced disorders of oxygen dependent processes in soft and hard periodontal tissues. It was revealed the strong activation of superoxidedismutase and catalase by Thiotriazolin, which determines its powerful antioxidant effect. These data can serve as an experimental rationale for using Thiotriazoline and Actovegin in stomatological practice to correct metabolic disorders in periodontal tissues.