Zaets T. Mechanisms of cryopreserved fetal nerve cells influence on the functional state of the liver in early cranioskeletal injury

Thesis is devoted to the pathogenic peculiarities of cranioskeletal injury and trauma complicated by hemorrhage influence on the functional state of the liver and reasoning the role of fetal cell therapy in reducing of the hepatic dysfunction manifestations. It is proved that in response to cranioskeletal injury in the acute phase and during the early manifestations of traumatic disease the biliational, biliary excretional, absorbingly excretory and glycogen-synthesizing liver functions are significantly disturbed especially in 3 and 7 days of post-traumatic period. Complications of cranioskeletal injury by further blood loss increase and accelerates the effects of liver dysfunction which appears in the first day of post-traumatic period. In the presence of cranioskeletal injury without additional blood loss the intake of fetal nerve cells leads to improvement of the most studied findings of functional state of the organ. In the presence of cranioskeletal injury with additional blood loss the use of fetal nerve cells is accompanied by a fundamentally similar positive action, but according to the dynamics of the studied findings the positive action has been observed from the third day. The comparison of fetal cell therapy in animals with cranioskeletal injury and trauma complicated by hemorrhage due to the deviation amplitude of the studied findings revealed for the first time higher efficacy of the proposed correction method on a background of trauma with additional blood loss.