Korzh I. Diagnostic value of immunoinflammatory disorders and their correction in osteoarthritis patients with arterial hypertension and obesity..

The thesis deals with the study of significance of immunoinflammatory mechanisms in the pathogenesis of osteoarthritis of big joints (hip, knee) in patients with arterial hypertension and overweight and obesity. The research also considers the influence of atorvastatin on the degree of system immune inflammation in patients during complex treatment of patients at stages I-III of osteoarthritis in combination with hypertension and obesity. It was found that in the blood of patients at I, II and III stages of osteoarthritis in combination with hypertension and obesity there was increase of acute-phase indicators - fibrinogen, glycoproteins, sialic acid, haptoglobin, C-reactive protein, as well as markers of destruction of connective tissue - chondroitinsulfates, excretion of hydroxyproline and uronic acids. The highest degree of immunoinflammatory disorders was found in patients at stage III of osteoarthritis in combination with hypertension and obesity: besides the above indexes these patients also increased blood levels of IL-4. Patients at stages I-II of osteoarthritis with hypertension and obesity had dyslipidemia of II A subtype, which is characterized by increased low-density lipoprotein in serum levels, which is the main form of lipoproteins that transport cholesterol into the blood. In patients with osteoarthritis of big joints at the third stage, in combination with hypertension and obesity there develops dyslipidemia of II B subtype. Taking nonsteroidal antiinflammatory drugs, antihypertensives combined with atorvastatin at a daily dose of 20 mg for correcting dyslipidemia by patients at I, II and III stages of osteoarthritis in combination with hypertension and obesity helped reduce system inflammation and degradation of cartilage affected joints.