Reizin D. Clinical management of patients with medullary carcinoma of the thyroid gland: aspects of diagnosis, course of the disease,treatment

Object of the study: medullary carcinoma (MC) of the thyroid gland (TG), diagnosis and treatment. Aim of the study: to justify and establish prognostic factors of the disease, as well as criteria for determining the optimum volume and surgical treatment of patients with thyroid MK at different by nature of the disease. Research Methods and apparatus: clinical, retrospective, Immunoassay, mathematics and statistics; ultrasound machine "Aloka», «Calcitonin ELISA». Theoretical and practical results: retrospective analysis of the results of examination and treatment of patients with thyroid MK possible to establish the main prognostic factors of the disease, which are the sex of the patient, the genesis of sporadic tumors, postmenopausal patients, the presence of micrometastases at diagnosis. The obtained results allowed the author to introduce clinical-diagnostic algorithm of patients with medullary carcinoma of the thyroid, which takes into account the size of the primary tumor, to determine the extent of surgical vmeshatelststva to regional lymph of collectors. Proved the value of research concentration of calcitonin in the blood for the purpose of diagnosis and early detection of MK postoperative metastasis. Novelty: Based on the observation of a large group of patients with thyroid MK proved znachanie size of the primary tumor to determine the extent of surgical intervention on regional lymph of collectors. It is found that among patients with thyroid MK more women, some of whom sporadic MC with age becomes substantially smaller and more often occurs multifocal tumor growth and bilateral disease cancer. It is found that male gender is a poor prognostic factor concerning the development and prognosis of the disease. Determined that the serum calcitonin postoperative Viseu 100 pg / ml indicates the presence of tumor metastases. Degree of implementation: The results of the study are introduced into clinical practice SI "Institute єndokrinologii and Metabolism. VP Komissarenko NAMS of Ukraine "and in the Department of Surgery of the Kiev city clinical hospital №8. Sphere of application: endocrinology.