Matsko N. Pathogenetic features of periodontitis in patients with gastroduodenal ulcers

Object - inflammation of periodontal tissue in patients with gastroduodenal ulcers; purpose - establish the role of oxidative, immune and cytokine disturbances in the mechanisms of periodontitis in patients with gastroduodenal ulcers; methods - clinical, laboratory, instrumental, bacterioscopic, polymerase chain reaction, biophysical, enzyme immunoassay, immunological, biochemical, statistical; Results - new data about the mechanisms of inflammatory and inflammatory and degenerative processes in the maxillofacial region in terms of gastroduodenal pathology, depending on the severity of the course; complement the current data about their pathogenesis, interdependence mechanisms of their development, given the overall contamination by bacteria H. pylori. First to demonstrate that in patients with gastroduodenal ulcers associated with H. pylori infection develops more significant inflammatory and destructive periodontal tissue damage; progression of inflammation in patients with chronic generalized periodontitis depends on H. pylori in the presence of periodontal pockets and phase duration and comorbidity. Found a violation of the balance between pro- and antioxidant systems in patients with gastroduodenal ulcers, which are depressed with the appearance of inflammatory and dystrophic processes of periodontal tissues. About unfavorable course of periodontal disease on the background of gastroduodenal ulcers suggests reduction of T-lymphocytes and their functional activity, cytokine imbalance of local and general values, Ig A persistent increase and decrease of lysozyme in the studied biological fluids; inadequate immune response in low H. pylori eradication leads to the progression and chronicity of the pathological process in the periodontium.