Shandra O. Role of disorders of the immune and nervous systems in the allergic dermatitis pathogenesis and their pharmacological correction

This thesis is devoted to the determination of the functional role of central nervous system disorders and immune-responsiveness in the pathogenesis of allergic dermatitis, and development of a treatment based on the combined use of delta sleep-inducing peptide and melatonin. It has shown that experimental chrome-induced allergic dermatitis in rats is characterized by behavioral disturbances, altered sleep structure, and reduced duration of the phases of the sleep-wake cycle. It has found significant impairments of the humoral and cellular immunity, and reduced functional stability of neutrophils and lymphocytes. A synergistic combination of delta sleep-inducing peptide and melatonin normalized the functional activity of the nervous and immune systems. Patients with allergic dermatitis showed changes of morphometric, functional, and fluorometric skin parameters. These patients had impaired immune status, emotional disorders, and changed serum concentrations of thyroid-stimulating hormone, triiodothyronine, thyroxine, and dehydroepiandrostenedione. The combined delta sleep-inducing peptide and melatonin treatment effectively normalized these parameters.