Kolupayev S. Improvement of the diagnostics of overactive bladder in women based on the definition of the pathogenetic factors of the disease.

The thesis is dedicated to the improvement of diagnostics of overactive bladder (OAB) in women. On the basis of clinical, laboratory and instrumental examination of 107 women with overactive bladder the main pathogenetic factors of the disease were found and scientifically proved the following pathogenetic types of the development of OAB in women: inflammatory, dysgemic, dyshormonal, mixed. The elevated urinary concentration of IL-8 and MCP-1 was proved to be markers of the inflammatory component in the development of OAB. The pathogenetic role of the hypoestrogenism in the genesis of OAB in 26,47% of women of reproductive age was found. The reography of the bladder wall was proved to be an appropriate method for the diagnostics of the dysgemic type of the OAB. The characteristic changes of arterial and venous blood flow that accompany the development of symptoms of the disease were found. The developed diagnostic and treatment algorithm is recommended for use in case of symptoms of OAB in women.