Herasymova O. Improvement of pathogenetic therapy of bronchial asthma in school-age children based cardiovascular safety profile

This research focuses on cardio - vascular system in children of school age, depending on the level of asthma control. Identified certain patterns of violations of cardio - vascular system in children with uncontrolled asthma. The assessment of cardiovascular safety of the combination of beta-2 agonists and long-acting inhaled corticosteroids with long-acting methylxanthine derivatives in acute asthma and received clinical evidence of the effectiveness of budesonide/formoterol fumarate in combination with doxofylline in the treatment of school-age children with uncontrolled asthma who had no effect of beta 2 - agonists short-acting and identified changes in the cardiovascular system. Based on the selected priority areas correction of cardiovascular disorders in children with uncontrolled asthma was assessed the effectiveness of cardiotropic complexes that must be used depending on the changes of the cardiovascular system, in compliance background of basic therapy. In the therapeutic group, in which children received budesonide/formoterol fumarate in combination with rhythmocor for 3 months significantly reduced the number of clinical symptoms, such as palpitations, a feeling of "disturbance of the heart", weakness, decreased frequency of sinus tachycardia, supraventricular arrhythmia, prolonged QT interval, which resulted in improvement in cardiac output and cardiac index and normalization of central and cerebral hemodynamics and was associated with increased levels of K+ in serum and in the blood However, in the therapeutic group in which children received budesonide/formoterol fumarate in combination with thiotriazolinum for 3 months significantly reduced the number of complaints of a headache, decreased frequency of sinus bradycardia, decreased levels of markers of myocardialinjury, increased tricuspid annular plane systolic excursion systolic excursion to 2,39 0,01 cm, indicating a more clinical efficacy of this treatment regimen in children with uncontrolled asthma and related changes in the cardiovascular system.