Chaplia O. Developmental characteristics of cultured in vitro human embryos possessing numerical chromosome abnormalities.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0414U006043

Thesis Registration Form

0414U006043.pdf

Applicant for

Specialization

  • 03.00.11 - Цитологія, гістологія

23-12-2014

Specialized Academic Board

Д 26.254.01

Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine

Essay

The dissertational study focused on morphologic features of in vitro cultured human embryos regarding their chromosomal status. It was established that only 34,2 % of examined embryos were euploid according to 13, 16, 18, 21, 22 and sex chromosomes' number. The low effectiveness of genetically balanced embryos selection based on their morphologic characteristics on the second and third day of culture was demonstrated. The relative increase of chromosomally balanced samples in general cohort of embryos after their prolonged culture was established using the range system for embryo quality evaluation. There has been revealed a direct relation between the increase of mothers' age and the frequency of chromosomally unbalanced embryos formation. The results represented in this work can be used in clinical practice to increase the efficiency of infertility treatment.

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Files

aref.doc

dis.doc

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