Matolinets T. Peculiarities of changes in functional condition of prooxidant and antioxidant systems in the spleen, bone marrow, and thymus at late periods of experimental allergic alveolitis development and their correction with corvitin.

Object - the process recreated on porpoises with use of experimental model allergic alveolitis; the purpose - to define a role and features of changes of prooxidant and antioxidant systems in bodies of breath in pathogenetic developments experimental allergic alveolitis and to establish their correction with corvityn; methods - biochemical, mathematical; results - The research deals with substantiation of the role and peculiarities of disturbances of oxidant and anti-oxidant systems' functional condition in immune organs in pathogenesis of experimental allergic alveolitis and their correction with corvitin. Gradual excessive formation of lipid peroxidation products, which started from the 74th day of experiment and achieved the highest index on the 94th day, at the same time gradual decrease in activities of superoxide dismutase, catalase, peroxidase, ceruloplasmin, and glutathione reductase, which was the most manifested in central (bone marrow, thymus) and less in peripheral immune organs (spleen, paratracheal lymph nodes) from the 74th to 94th days of experimental allergic alveolitis development have been shown for the first time. Positive corrective influence of corvitin on deviated condition of lipid peroxidation and antiradical defence has been proved for the first time, which was manifested by increase in activities of catalase, superoxide dismutase, peroxidase, ceruloplasmin, glutathione reductase and decreased level of malonic dialdehyde and diene conjugates in bone marrow, thymus, spleen, and paratracheal lymph nodes in experimental allergic alveolitis.