Zhukova N. Pathogenetic therapy in patients with diffuse psoriasis by correction of metabolic processes indicators

The object of study - common psoriasis. The purpose of study - improving the efficiency of the treatment of patients with psoriasis develop pathogenetically substantiated by complex method of therapy based on the study of clinical and pathogenetic features of the disease, state of adaptation, carbohydrate, lipid, protein and ion exchange. Methods: clinical, anthropometric, biochemical, physical, chromatography, immunoenzyme, statistical. The thesis is devoted to scientific problem solution such as increase of the treatment effectiveness by aminoacid complex in patients with psoriasis based on the researches of adaptation conditions malfunction as well as protein, carbohydrate, lipid and ion metabolism disorders. Those malfunctions has been shown by insufficient disposal of nitrogen metabolism products, liver and kidney disorders, both of kynurenine inhibition and serotonin activation of tryptophan metabolism and its metabolites probably having influence to epithelium proliferation and polysystemic affection. Clinical manifestations features with metabolic syndrome signs and insulin-like growth factor - 1 role in pathogenesis are revealed. Cardonate treatment has been scientifically justified and approved; its efficacy has been confirmed by clinical remission reduction and by metabolic processes indicators correction. The results have been implemented in practice of MIHC "Kharkiv City Dermato-venerological Dispensary no. 1", MIHC "Kharkiv City Dermato-venerological Dispensary no. 5", MIHC "Regional Clinical Dermato-venerological Dispensary no. 1" (Kharkiv). Area of use - dermatology.