Petrynych V. The character of the toxic effects in rats with various type of acetylation under conditions of subacute exposure of manganous chloride and lead acetate and prevention of intoxication by means of quercetin

The thesis deals with the studying peculiarities of individual susceptibility to the toxic action of manganese chloride and lead (II) acetate in rats with various type of acetylation under conditions of subacute experiment. Subacute manganese chloride intoxication in the doses of 5 mg/kg and 50 mg/kg in mature rats with "slow" and "rapid" types of acetylation was found to be accompanied by the decreased indices of behavioral reactions, and increased processes of free radical oxidation and antioxidant defense (AOD) in the blood and liver. The biomarkers of lead (II) acetate harmful effect in the doses of 2,5 mg/kg and 15,5 mg/kg on mature rats under conditions of subacute intoxication are: reduced indices of behavioral reactions, increased level of delta-aminolevulinic acid in urine, intensified processes of protein oxidative modification (POM) and lipid peroxidation (LPO), decreased content of HS Group in the blood, reduced indices of POM, LPO and AOD in the liver. The "rapid" type of acetylation is a susceptibility marker to manganese chloride and lead (II) acetate toxic action under conditions of subacute experiment on mature rats. The research substantiates a preventive administration of quercetin under conditions of subacute manganese chloride effect in the dose of 50 mg/kg and in modeling lead intoxication in the dose of 15,5 mg/kg. A preventive administration of quercetin was proved to be able to decrease toxic effects in modeling the above mentioned intoxications both in "slow" and "rapid" acetylators.