To achieve the objective and the decision of tasks, 127 patients with stage II AH of 2-3 degree were examined, among whom were 57 (44.9%) men and 70 (55.1%) women aged 20 to 72 years. Inclusion criteria for investigation were the presence of essential hypertensions of stage II of 2-3 degrees at high development risk, which in the previous therapy, the BP target level was not achieved. Diagnosis of hypertension stage II is based on the presence of retinal angiopathy and transient proteinuria. Cardiac involvement (hypertensive heart) on admission to hospital was diagnosed on the basis of clinical, ECG and echocardiography investigations in 90.6% of patients. In clinical practice, we used the method of daily monitoring of blood pressure, which provided additional opportunities assessing the level of blood pressure during the day, determine the relationship between changes in blood pressure and heart rate (HR), morning peak and the impact of medical methods on parameters of ABPM. New scientific results were obtained. They solve important task of modern cardiology, which is to improve the effectiveness of treating patients with AH of stage II by means of learning the clinical course of the disease, heart rate variability, hemostasis system and blood lipid spectrum. Their correction with combined antihypertensive treatment that include Tonorma and amaranth oil plays an important role. The statistical analysis of causes of the risk of arterial hypertension in patients with AH of stage II of degree II-III revealed increase in sympathetic tone level of VNS (significant decrease of SDNN, rMSSD, pNN50% and increase in LF and LF / HF). It was also obtained that decresing in frequency spectrum (HF) that characterizes parasympathetic regulation of heart rate. During the research in patients with hypertension of II stage increased procoagulant level and reduced anticoagulant and fibrinolytic activity of the blood were found. Established that vascular-platelet element of hemostasis broken not by the total number of platelets, but violations of their adhesively-aggregation properties. Found hypercholesterolemia and atherogenic dyslipidemia - the main risk factors for atherosclerosis leading to the progression of hypertension From a therapeutic purpose, patients received antihypertensive treatment (drug Tonorma 0.5-1 tablet daily for 30 days) in combination with amaranth oil (1 teaspoon three times a day, 20 minutes before a meal - 30 days). The use of a therapeutic agent Tonorma contributes to the target level of blood pressure, variability normalization of systolic and diastolic blood pressure, indices of time with a load of daily, night, day and night averages of pressure. When applying Tonorma combined with amaranth oil achieved target blood pressure was observed in 59 (83.1%) patients out of 71 and when receiving Tonorma without amaranth oil - in 40 (71.4%) of 56. Taking of Tonorma in combination with amaranth oil helps to normalize the neurohormonal disorders, restores sympato-parasympathetic VNS balance, improves cardiac function by a statistically significant reduction in variability of SBP and DBP, on average, 26.6% and 27.7%. Appointment of the drug Tonorma in the combination with amaranth oil promotes reduction in procoagulant and an increase in anticoagulation and fibrinolytic activity of hemostasis system to a greater extent than without amaranth oil, eliminates dyslipidemia and normalizes lipid spectrum of blood. The use of amaranth oil in conjunction with antihypertensive drugs Tonorma strengthens its positive effect.
