Chekhovska G. Onychomycoses: early diagnostics and complex treatment with allowance for structural changes of nail plates and an agent kind

The object of study - the various forms of onychomycoses. The purpose of study - optimizing diagnostic and therapeutic care to patients with onychomycosis due to the use of the polymerase chain reaction, epiluminescent diagnostics and drugs that improve the structure of the nail plate. Methods: analysis of complaints, anamnesis of life and disease, evaluation of the objective status of the patient, clinical, biochemical, mycological, molecular, epiluminescent diagnostics, statistical methods. The thesis is devoted to problems of effective treatment of patients with onychomycoses by a speeding-up and an improvement of diagnostics and the development of a complex method of treatment of such patients. Dermatoscopic probes have allowed separating the structural changes in the nail plates affected by mycelium, so that a rating scale of severity level of an onychomycosis has been developed. Studying of sensitivity, specificity and diagnostic accuracy of polymerase chain reaction with panfungal primers and specific to Trichophyton rubrum primers have been made by the comparative analysis with the standard regulated methods of a mycological examination. There has been offered the new complex method of treatment of onychomycoses with application of both systemic antimycotic and means which enrich the structure and accelerate the growth of a nail plate. The results have been implemented in practice of clinics of SE "Institute of Dermatology and Venereology of NAMS of Ukraine", MIHC "Regional Clinical Dermato-venerological Dispensary no. 1" (Kharkiv), MIHC "Kharkiv City Dermato-venerological Dispensary no. 1", MIHC "Kharkiv City Dermato-venerological Dispensary no. 2", MIHC "Regional Dermato-venerological Dispensary" (Dnipropetrovsk), Kyiv City Clinical Dermato-venerological hospital. Area of use - dermatology.