Vepryuk Y. Age peculiarities of renal functions at combined action of aluminum and lead salts (experimental research)

Object - mechanisms nephrotoxicity combined effect of salts of aluminum and lead in rats of different ages; purpose - to determine the nature of the changes excretory, ionregulating and acidregulating renal functions in mature rats and immature the combined action of aluminum salts and lead in different functional states of the pineal gland and melatonin's effect set as a means of pathogenetic correction; methods - experimental, physiological, chemical, statistical; results - additional administration of aluminum salts on the background of lead salts is characterized by less nephrotoxic influence with decreased level of proteinuria and loss of sodium ions with the urine in mature and immature rats; hypofunction of pineal gland causes more substantial nephrotoxic effects of lead salts in the kidney of mature rats with more significant proteinuria syndrome and loss of sodium ions with the urine; at the same time, under the pineal gland hyperfunction, nephrotoxic effects of lead salts were less significant; protective effect of melatonin on excretory, ionregulating and acidregulating renal functions at the conditions of lead and aluminum salts administration is more efficient in mature rats towards immature animals, that manifested in increased level of diuresis, decreased level of protein excretion, increased level of titrated acids excretion as well as sodium ions distal reabsorption in mature rats in the absence of these effects in immature animals.