Duda K. Pathogenetic peculiarities of acute periodontitis according to background streptozotocin induced diabetes type 2

Object – acute periodontitis on background of type 2 diabetes; purpose – the state of nonspecific host defense, indicators of cellular, humoral immune system, lipid peroxidation process intensity, activity of components of the antioxidant system, features of cytokine profile in rats with acute periodontitis on the background of streptozotocin-induced diabetes type 2 was investigated; methods - experimental, biochemical, enzyme-linked immuno sorbent assay, cytofluorymetrical, cytological, morphological, statistics; results – showed us, that concomitant hyperglycemia leads to increase of intensity of oxidative processe compared with animals in which normal blood sugar level, that showed an increase in the intensity of the production of reactive oxygen species, intermediate and end products of lipid peroxidation. At the same time there is significant inhibition antioxidant protection, that showed decrease superoxide dismutase and catalase activity of blood and gums homogenate, concentration of ceruloplasmin and glutathione. Modeling acute periodontitis on background type 2 diabetes impairs functional status of neutrophils, accompanied by lower levels of NBT-test, progressive increase in proinflammatory cytokines (TNF-?, IL-1?, IL-6) on the background of reducing the concentration of IL-4 and IL-10 enhanced endogenous intoxication. Based on an analysis of the major pathogenetic links of acute experimental periodontitis that occurs on a background of diabetes type 2, we propose new pharmacological agent for its correction – combined pills containing extract of echinacea, zinc asparaginat and ascorbic acid, the use of which has positive effect on the studied parameters.