Chornovil A. Clinico-pathogenetic features and methods of treatment of atopic dermatitis in patients with chronic herpesvirus infection

The object of study - atopic dermatitis. The purpose of research - improving the effectiveness of therapy of atopic dermatitis in patients with chronic herpes infections (cytomegalovirus, Epstein-Barr-virus) based on the study of pathogenetic features of dermatosis and application in treatment of narrowband phototherapy combined with topical calcineurin inhibitor and liposomiс recombinant alfa-2b interferon. Methods: physical, biophysical, electro-physiological, immunological, molecular biology, statistics. The thesis is dedicated to increasing the efficiency of treatment of atopic dermatitis in patients with chronic herpesvirus infection. Revealed dependence of the level interleukin-1beta of allelic polymorphism (Arg753Gln) TLR-2 gene. It is shown that chronic herpesvirus infection affect the degree and severity of the atopic dermatitis, the risk of moderate and severe atopic dermatitis is related to sex and age of the patient, the level of interleukin-6, allelic polymorphism Glu429Ala gene MTHFR. Shown the interrelation of the severity of atopic dermatitis in patients with chronic herpesvirus infection and genotype Arg/Arg gene TLR-2. A complex treatment of patients with atopic dermatitis and chronic herpesvirus infection, which promotes the clinical remission in 64,4 % of patients, compared with conventional therapy - in 31,8 % of patients. Results of the study are introduced into the practice of MI "Zaporizhzhia Regional Clinical Skin and Venereal Dispensary" of Zaporizhzhia Regional Council, MI "Dnipropetrovsk Regional Children's Hospital of Dnipropetrovsk Regional Council", Poltava Regional Clinical Dermatovenerologic Dispensary, MCTPI HC "Regional Dermatovenerologic Dispensary" (Donetsk), MI "Rivne Regional Skin and Venerological Dispensary" of Rivne Regional Council. Area of use - dermatology.