Poda O. Clinical and genetic criteria for prediction and diagnosis of nonalcoholic fatty liver disease in children.

The thesis is devoted to the actual problems of modern pediatrics - improving the quality of life of children, prevention of nonalcoholic fatty liver disease in patients with exogenous-constitutional obesity by improving forecasting system disease. Based on a thorough analysis of anamnesis the main risk factors for nonalcoholic fatty liver disease (NAFLD) in children. Enhanced understanding of the clinical course of nonalcoholic fatty liver disease in childhood and adolescence, which in most cases are asymptomatic, with no complaints specific to this nosology. It is proved that NAFLD development in children occurs on a background of severe disorders of carbohydrate and lipid metabolism as the main components of the metabolic syndrome (MS). Proven role of proinflammatory cytokine TNF-a as an important marker adypotsytarity dysfunction in children with abdominal type of obesity. According to the results of genetic examination findings that the presence of "mutant" allele 12Ala PPARgama2 gene in children with obesity is associated with a lower risk of metabolic abnormalities in insulin resistance and dyslipidemia form and lower rates of proinflammatory cytokine TNF-a. Based on a comprehensive analysis of the clinical and paraclinical parameters created an algorithm that reliably with 95% allows to predict the development of nonalcoholic fatty liver disease in children.