Andreeva K. Synthesis, chemical transformations and biological activity of 3-(3-R-carbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)-propanoic acids and their derivatives

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U002488

Thesis Registration Form

0415U002488.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

14-05-2015

Specialized Academic Board

Д 64.605.01

National University of Pharmacy

Essay

The thesis is devoted to the purposeful search for new biologically active substances in the series 3-(3-R-carbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)-propanoic acids, their amides and nitriles. Based on the investigations preparative methods of production of new compounds has been developed, a new environmentally appropriate and adapted to industrial production technology of synthesis of ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids has been proposed, in the study of analgesic and diuretic properties of the synthesized substances an important patterns of "structure and biological action" have been determined, methods of qualitative and quantitative analysis of advanced substance have been developed.

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Files

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