Konoplitska A. The meaning of markers of cell membrane damage nephrothelial in the differential diagnosis of kidney disease with hematuria syndrome in children.

The thesis is dedicated to the differential diagnosis of renal diseases with hematuria syndrome in children based on the determination of cell's membranes damage in nephrothelii with the study of biochemical markers of glomerular and nonglomerulyar hematuria. Diagnostic value of urinary beta 2 -MG, Che, gamma-GT and MDA content in serum of blood was defined to identify the glomerular and nonglomerulyar pathology in children with renal diseases with hematuria syndrome. It is proved that the increased excretion of ChE and increased MDA content with the serum of blood of children with the syndrome hematuria indicates the damage to the cell's membranes of the glomerular apparatus of the kidney and is a marker of glomerular hematuria in children. Increased excretion of gamma-GT, the level of beta 2 -MG urine and increased content of MDA in the serum of blood of children with the hematuria syndrome indicates damage to the cell's membranes of nephrothelii proximal tubules and is a marker nonglomerular (tubular) hematuria in children. The study of these laboratory parameters in children with unspecified hematuria helps to determine in what parts of cell's membranes exactly nephron damage happened. Developed and offered in practical health algorithm of differential diagnosis and a mathematical model of predicting renal hematuria for examination of children with hematuria syndrome.