Kugler S. Sustainable integrated assessment of the effectiveness of intensive care of acute ischemic stroke

The thesis is devoted to the criteria development for predicting the course of stroke and neuroprotection optimal scheme in the acute phase of the evaluation of their effectiveness. Goal of the study was conducted by improving the diagnosis of functional state of the central nervous system, the degree of dysfunction of the blood-brain barrier (BBB) and the optimization algorithm of intensive therapy (IT) with the inclusion complex neuromethabolic drugs, increasing the efficiency of treatment of patients with acute ischemic stroke. It was shown the value of different ways to diagnose the severity of ischemic stroke, namely the evaluation of neurological deficit using neurological scales, quantitative EEG, assessment concentration neuron-specific proteins NSE and GFAP during the treatment, and the developed determination of antibody titer to the brain autoantigens.