Kravchuk B. Biventrical pacing for heart failure treatment

This dissertation is the first national study of the role of biventricular pacing in patients with chronic heart failure. In the study group we included 124 patients who were treated in our clinic between 2003-2011 years. Cardiac dyssynchrony is complex and multifaceted. If ventricular contraction is delayed, then LV diastolic pressures will exceed atrial pressure causing diastolic mitral regurgitation. The loss of ventricular pre-load then leads to a reduction in LV contractility. Both inter- and intra-ventricular conduction delays lead to asynchronous contracion of LV wall regions (ventricular dyssynchrony), impairing cardiac ef?ciency and reducing stroke volume and systolic blood pressure. Poorly coordinated papillary muscle function may cause or aggravate functional systolic mitral regurgitation. Impaired performance promotes adverse LV remodelling.