Sokol M. Optimization of reproductive function recovery techniques in women with polycystic ovarian and tubal-peritoneal infertility.

The thesis for the degree of medical science is devoted to the actual, both in scientific and practical aspects, problem of reproductive disorders in women with PCOS and tubal-peritoneal infertility, methods of adhesive process prevention and rehabilitation techniques in the postoperative period after laparoscopic treatment. The author developed a new method of adhesive process recurrence prevention in women with PCOS and tubal-peritoneal infertility, based on conducted experiments, which includes the use of radiowave energy, argon plasma coagulation (APC) after 1/3 ovarian resection with intraoperative administration of polyethylene oxide with sodium carboxymethylcellulose (PEO with CMC) for adhesions prevention. The author developed a method of reproductive function rehabilitation in patients with combination of PCOS and tubal-peritoneal infertility, which includes the use of L-arginine, combined oral contraceptives with antiandrogenic effect and myostimulation of fallopian tubes contractile function. A comparative assessment of combination of the radiowave energy or APC, conventional methods of intraoperative adhesions prevention or administration of a polyethylene PEO with CMC for the adhesions prevention in patients with combination of PCOS and tubal-peritoneal infertility was conducted. The best treatment results in reproductive age patients with combination of PCOS and tubal-peritoneal infertility obtained while both APC and PEO with CMC, for adhesions prevention, were administered intraoperatively in combination with author proposed method of postoperative rehabilitation. Uterine pregnancy occurred in 62.5% of patients with PCOS and in 52.9% patients with combination of PCOS and tubal-peritoneal infertility.