Chuprina L. Neurological manifestations of microprolactinomas pituitary in women of average reproductive age

Microprolactinoma is the most common function in pituitary adenoma. In the chain of pathogenic events, developed during microprolactinoma functioning, hyperprolactinemia is a key element. Hyperprolactinemia starts a number of neuroendocrine changes, which are clinically manifested by menstrual and subsequently, reproductive functions; pathological changes in the mammary glands; endocrine disorders; ocular changes. Undeservedly little attention has been paid to neurological and psycho-affective disorders, which, according to our observations, occur under the described syndrome in more than a half of cases. Pathogenetic aspects of the development of these disorders are not clear. We have analyzed 52 cases of pituitary microprolactinomas in female patients of reproductive age. Clinical performance of neurological manifestations in this group of patients, depending on the extent of the defect in hormonal state, has been also analyzed. It is shown, that the described complex of disorders is often obligate for female patients of reproductive age with pituitary microprolactinomas, and it can be presented to patients without references to concomitant gynecological signs, which require an interview in order to determine ovarian menstrual cycle disorders as a clinical criterion of hormonal state disorder in female patients of the group.