Soroka I. Morphofunctional changes in cerebral cortex under conditions of chronic endotoxemia.

Dissertation is focused on determination of pathogenic mechanisms of systemic immunoreactive and metabolic disorders and its role in the development of morphological changes in somatosensory cortex of white rats with chronic endotoxemia and confirmation of efferent detoxicating therapy efficiency for correction of revealed disorders. Chronic endotoxemia induces significant metabolic and immunoreactive disorders that are characterized by excessive synthesis of serum immunoglobulins, pro- and antiinflammatory cytokines, significant reduction in non-specific cellular immunity and the accumulation of immune complexes, increasing the amount of CD3-lymphocytes in the phases of apoptosis and necrosis. It also initiates activation of oxidative stress manifestations and mediators imbalance in enzymatic and glutathione-related links of antioxidant system. Neurocytes and glial destructive affection with microcirculation disorders are typical for structural changes in cerebral cortex at the cellular and subcellular levels.The effectiveness of application of carbon enterosorbent “Carboline” under conditions of chronic endotoxemia is experimentally confirmed: it is observed the decrease of evidence of oxidative stress, metabolic and immune disorders, reduce of the amount of CD3-lymphocytes in the phases of apoptosis and necrosis, decrease of neuronal tigrolysis in ganglion and pyramidal layers of the cerebral cortex, increase the amount of normochromal neurocytes and normalization of hemocapillaries state, neurocytes reparative regeneration processes are noted.The improvement of structural organization of somatosensory zone of parietal area of the cerebral cortex causes the restoration of nociceptive reactivity among test animals under temperature impact.