Pohoretska Y. Pathophysiological mechanisms of liver damage in experimental bronchial asthma and their correction with thiotriazoline

The research highlights the role and peculiarities of disturbances of pro-oxidant and antioxidant systems and transaminase activity in the liver and certain indices of endogenous intoxication, protein, lipid and pigment metabolism in the blood in pathogenesis of experimental bronchial asthma and their correction with thiotriazoline. It has been established that in experimental bronchial asthma a gradual excessive production of free radical oxidation products in the liver occurs with the highest level of manifestation on the 32 day of experiment with compensatory increase (18 day), and further (25 and 32 days) – a noticeable decrease in activity of antioxidant protection. It has been detected that disturbance of intact hepatocyte membrane and release into the blood of intracellular enzymes – alanineaminotransferase and aspartateaminotransferase, activity of which didn’t exceed the norm and increase in endogenous intoxication in the bodies of the animals, elevation of globulins in the blood, general bilirubin and cholesterol, and reduction of the level of general protein, albumins and urea, especially on the 32 day, are observed in all periods (18, 25 and 32 days) of bronchial asthma. It has been proven for the first time that injection of thiotriazoline has a positive impact on violated indicators of metabolic processes both in the liver and in the blood in experimental bronchial asthma.