Andriychuk N. Toxicological-hygienic assessment and prophylaxis of harmful effect of silver nanoparticles, got by means of method of photostimulated synthesis

In thesis work there was grounded the expediency of taking into account the physical and chemical properties of silver nanoparticles, including geometrical characteristics (shape, specific area of surface), the number of silver ions in nanoparticle and the quantity of nanoparticles in the solution while the determination of exposition of nanosilver or other nanochemicals of different geometric shapes. Acute toxicity of nanosilver of different shapes was researched. DL50 for mice of spheral and decahedron silver nanoparticle, 45 and 75 nm, intraperitoneal injection is higher than 11,9 mg/kg. On models of subacute effect there were determined the peculiarities of different shape nanosilver exposure and hygienic meaning of biochemical and pathomorphological changes as criteria of harmful effect. With the help of morphometric analysis of pathomorphological changes of internal organs of rats there was ascertained doserelated harmful effect of decahedron silver nanoparticles. There was realized the assessment and proved the effectiveness of prophylactic usage of alpha lipoic acid for the decreasing of harmful effect of silver nanoparticles.