Rymar M. Complexation of nimesulide, meloxicam, ibufrofen with high molecular compound and modification of solubility of substances

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U000348

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

04-02-2016

Specialized Academic Board

Д 17.600.03

Zaporizhzhya State Medical University

Essay

The thesis is devoted to developing ways to increase the solubility of nimesulide, ibuprofen and meloxicam and studied their complexation with macromolecular compounds. Developed and scientifically sound methods of obtaining solid dispersion systems for pharmaceutical use substances based on polyvinylpyrrolidone, polyethylene glycol and cyclodextrin. Developed and validated spectrophotometric methods of quantitative determination of nimesulide, ibuprofen and meloxicam in solid disperse systems.

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