Cherniavska Y. Clinical and genetic mechanisms of systemic and organ hemodynamic disoders in premature infants with bacterial infections of early neonatal period.

The thesis is devoted to the early diagnosis of bacterial infections in premature infants optimizing from a study of the disease clinical course, determination the causes of organ and systemic hemodynamic disoders in it, as well as analysis of renin-angiotensin system (ACE, AGT2R1) and endothelial NO-synthase (eNOS) genes polymorphism contribution in the development of these states. The study has set up predictive model of early bacterial infections, which included risk factors, such as premature rupture of membranes, placenta visual changes, gestational age of the child, Apgar score, the level of monocyte> 6,5 % on first day of life. It was established that the development of arterial hypotension syndrome predetermined infectious status of the child (colonization St. epidermalis, level of monocytes in the blood), metabolic status (blood glucose <2.8 mmol/l, pH <7,2), as systemic and organ blood flow (stroke index of left ventricle below the age limit and reduce ACM IR less than 0,67). Early bacterial infections in premature infants is not associated with ACE, AGT2R1 and eNOS genes polymorphism, but with the development of arterial hypotension syndrome was significantly associated CC genotype of AGT2R1 gene.