Vasyliev O. Remodeling of hepatotoxic pathogenesis mechanisms of experimental peritonitis saturated with xenon

There was an experiment on the 290 white male rats of outbreed rarefaction (180-220 gr. each). It is stated that enlargement of experimental fecal or traumatic peritonitis is followed by structural and functional changes of test animals' internals. Inherently these changes are predominantly of dystrophic nature that is caused by enlargement of endogenous intoxication. The appearance of boosted capacity on its last legs was detected in lien. The enlargement of endogenous intoxication is connected with structural and functional appearance of lipoprotein liver dystrophy and inactivation process of breakdown products and xenobiotics transamination. Since reciprocal liver and internals changes (by nature) were detected by direct toxic effect on liver that is an inveterate alcoholic intoxication, the detected abnormalities of detoxification and protein synthesis hepatic function, apparently, are important pathogenic mechanism of multisystem pathology in peritonitis of different origin. A physiological solution lavage of rats' abdominal cavity saturated with xenon (with peritonitis of different origin) positively effected on the enlargement of pathologic process. It occurred in severe cut of test animals mortality, earlier (3 days) and more full dissolution of dystrophic internals changes, depression of lien capacity, although xenon wasn't inducing full dissolution of inflammation appearance. Positive xenon effect was connected with detoxification hepatic function maintenance, repression of catabolic processes activity (apparently, by means of cell membranes fastening) and thereby with disposing of endogenous intoxication. We think that positive xenon effect is connected with structural and functional hepatic cell membranes fastening and its effect on metabolic processes in liver through the influence on membrane receptors. As a confirmation of such hypothesis there are similar changes in liver and internals of animals. There was also a direct toxic effect on liver during the peritoneal lavage saturated with xenon. It should be noted that positive xenon effect in case of these animals is expressed less than in case of rats with peritonitis. It could be determined by continuous toxic effect of xenon lavage course delivery. As a result, xenon, effecting the state of cell membranes and kinesis of cell receptors, takes down intensity of endogenous intoxication and blocks enlargement of multisystem pathology in peritonitis of different origin.