The dissertation is devoted to solving an actual problem of establishing physiological and hygienic significance of microclimate of office premises, studying its effect of the human thermal state, indices of health of office workers and developing a set of preventive measures. It is established that the most prevalent unfavorable factors, affecting office workers are: microclimate (Class 3.1-3.4 by the General Classification of Labor), intensity of work (Class 3.1-3.2) and insufficient air ionization (Class 3.1). In warm periods of the year the high air temperature 1-3oC (Class 3.1) is recorded in office premises with conditioned air system; in premises without air condition - it is exceeding the standard up to 6-7oC (Class 3.2-3.3). In cold periods of the year work conditions in office premises correspond to Class 3.1 (34% work places) and Class 3.2 (59% work places). The signs of the heating microclimate are recorded in 88% work places, exceeding the standard air temperature by 0,1-4oC and with low air humidity - 23,5-37%. The most effective system for maintaining microclimatic parameters is a climate-control system of the type "chiller-fan-split system". In this, temperature, relative humidity and air motion velocity correspond fully to the ISO 7730:2005 requirements (for premises of "B" category). A split-system, on condition of its proper mounting and rational operation, is quite effective. Under the air temperature in offices 24-26oC in warm periods of the year significant do not occur any excesses of the permissible human thermal states (p<0,05). The dependence of thermal pain sensations (TPS) on the air temperature (T) can be presented by the following equation of the linear regression: T, points =+ 6,1762+0,4126 ? ToC. In cold periods of the year under the air temperature of 24-26oC the excess of the general body temperature in office workers by 0,6-0,7oC is recorded by the end of the working shift, pointing to the increased body sensitivity of the temperature factor. Office workers have complaints of the microclimatic conditions - 52,6±5,3 complaints per 100 workers, foreign noise - 25,5±5,1, insufficient artificial/natural illumination - 11,1±2,5 complaints per 100 workers. The incidence of complaints from workers on the organ of vision correlates with insignificant illumination at workplaces (r=-0,64, p<0,05); the rate of complaints on the respiratory organs, frequent catarrhal diseases correlate with the availability of draughts and high air motion velocity (r=0,63, p<0,05). A correlation relation between thermal sensation of workers and air temperature in office premises (r= 0,85, p<0,05) and work intensity (r=0,78, p<0,05) has been established. The rate of temporary morbidity among office workers is 1,51-1,63 times higher than the general for Kiev, and 2,00-2,16 times higher than in Ukraine in general (p<0,05).
