Suleiman M. Synthesis, physical and chemical, pharmacological properties of 3-oxamoyl (succinoyl)substituted ortho-chlorbenzoic, N-phenylanthranilic acids and their derivatives

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U001484

Thesis Registration Form

0416U001484.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

03-03-2020

Specialized Academic Board

Д 64.605.01

National University of Pharmacy

Essay

The dissertation is devoted to the synthesis of new biologically active and low toxic substances among derivatives of 3-carboxy-2-chloroxanilic (succinanilic) acids and substituted 3-oxamoyl(succinoyl)amides of N-phenylanthranilic acids, establishing the structure of the obtained substances by physical and chemical methods, the research of the reactivity and the study of its biological activity, establishing the consistent pattern of the connection structure-activity of the synthesized derivatives of N-phenylanthranilic acid as anti-inflammatory and analgesic means using QSAR-analysis and the mechanism of their action at the cellular and subcellular levels using the methodology of molecular docking.

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Files

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