Kononevich Y. Synthesis, transformations, physico-chemical and biological properties of derivatives of cyclopenta[d]pyrimidine-2,4(3H,5H)-dione.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U001936

Thesis Registration Form

0416U001936.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

08-04-2016

Specialized Academic Board

Д 35.600.02

Danylo Halytsky Lviv National Medical University

Essay

The thesis is devoted to the synthesis of new potentially biologically active 1,3, 3,7-disubstituted and 1,3,7-tri-substituted derivatives of 6,7-dihydro-1H-cyclopenta [d] -pirymidyn-2,4 (3H, 5H) - Dion, investigation of their physical, chemical and biological properties (studied antispasmodic, analgesic, anti-inflammatory, anti-tumor, antioxidant activity and acute toxicity). Using quantum-chemical calculations, correlation and regression analysis, it was shown a quantitative relationship between the structure of derivatives 6,7-dihydro-1H-cyclopenta [d] pyrimidine-2,4 (3H, 5H) -dionu and their spasmolytic activity; introduced in the educational process; area - pharmacy.

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Files

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dis_Kononevich.pdf

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