Yanchiy I. Clinical-morphological characteristics and results of treatment of well differentiated thyroid carcinomas after-preserved operations

The object of study: : surgical treatment of thyroid carcinoma (TC). Aim of the study: to justify the use of various surgical treatments of potentially radiation-induced differentiated thyroid cancer in subjects who were children or adolescents at the time of the Chernobyl accident. Methods and equipement: clinical, instrumental, surgical, morphological, statistical methods; “Toshiba” ultrasound machine; “Leica” microscope. Theoretical and practical results: the author has resolved an important scientific and practical problem regarding a personalized algorithm for treatment of patients with potentially radiation-induced differentiated thyroid cancer. The possibility has been shown, of cancelling final thyroidectomy (FTE) in cases of carcinomas with low potential of aggressiveness (solitary microcarcinoma and encapsulated papillary thyroid carcinoma (PTC), and the need for a radical intervention in multiple tumors (Tm) has been proved. A computer program, «ThyrProg», has been developed and introduced, allowing to reach consensus between the doctor and the patient as to the volume of surgery. Novelty: it has been demonstrated for the first time that solitary microcarcinomas and encapsulated PTCs which develop in subjects who were children or adolescents at the time of the accident, can be considered as tumors with low potential of aggressiveness. The possibility of cancelling FTE has been proved. The necessity for FTE performance is justified in those cases where after a preserving operation and final histologic diagnosis of "papillary carcinoma" there is evidence of multiple papillary carcinomas (Tm). Degree of implementation: the results of research have been introduced into clinical practice of specialized surgical units. A Patent of Ukraine under # 37908 and Author Certificate under # 57889 have been delivered. Sphere of application: endocrinology, surgery.