Feshchuk O. Clinical and genetic features of asthma in children, depending on the state of nonspecific hypersusceptibility bronchi.

Object - the bronchi hyperresponsiveness in children of school age with bronchial asthma; purpose - improvement of individualized treatment of bronchial asthma in schoolchildren with expressive and moderate hyperresponsiveness bronchi, based on clinical and paraclinical features of the disease and taking into account the predictive role of polymorphisms of genes GSTM1, GSTT1 and eNOS; methods - clinical, immunological, allergic-logical, spirometry, sputum induction, cytological, biochemical, molecular-genetic, sta-tistical; results - obtained new data on the effectiveness of the treatment of pupils, depending on the deletion polymorphism of genes GSTT1, GSTM1 and eNOS mutation; the effect of deletion polymorphism new phase II enzymes of biotransformation of xenobiotics GSTT1, GSTM1 and mutations in the eNOS variant of bronchial hyperresponsiveness (expressive airway hyperresponsiveness is 2.6 times more common in patients in the presence of deletions in these genes), as well as the nature of the response to desobstruktion and controlling therapy schoolchildren, patients with bronchial asthma; it demonstrated the feasibility of determining these children version hyperresponsiveness of bronchi, taking into account the polymorphism of enzymes of phase II detoxification of xenobiotics GSTM1, GSTT1 and eNOS mutation for the study and development of individualized approaches to leche-NIJ; it is recommended to use the diagnostic konstelyatsionnuyu table for verification expressive bronchial hyperresponsiveness, failing spirographic conduct studies in children.), as well as the nature of the dezobstruktivnuyu response to therapy and controlling schoolchildren with bronchial asthma; It demonstrated the feasibility of determining these children version hyperresponsiveness of bronchi, taking into account the polymor-phism of enzymes of phase II detoxification of xenobiotics GSTM1, GSTT1 and eNOS mutation for the study and development of in-dividualized approaches to treatment; it is recommended to use the diagnostic constellation table for verification expressive bronchial hyperresponsiveness, failing spirographic conduct studies in children.