Malchenko O. Pathogenetic substantiation of approaches for correcting damaged tissues in experimental lower-limb ischemia-reperfusion syndrome

The thesis is devoted to the problem of establishment of the role of proteolytic and free radical oxidation mechanisms in pathogenesis of reperfusion syndrome and experimental approaches to study the pathogenesis of medicine correction of this pathology by combined use of antioxidants, protease inhibitors and natural analogues of prostaglandin E1. The key pathogenetic proteolytic and free radical mechanisms of development of local muscle damage at experimental ischemic/reperfusion syndrome injury and their influence on the ultrastructural changes in the damaged area were revealed based on the results of experimental investigations. The pharmacological preconditioning by combined use of quercetin, aprotinin and natural analogue of prostaglandin E1 prevents biochemical, morphological and ultrastructural damage of skeletal muscle at ischemia/reperfusion syndrome.