Kozlova Y. Morpho-functional state of the hippocampus in the dynamics of experimental cardiomyopathy development

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U003505

Thesis Registration Form

0416U003505.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

22-06-2016

Specialized Academic Board

Д 17.600.04

Zaporizhzhya State Medical University

Essay

The pathogenetic connection between both behavioral and cognitive disturbances with hippocampal morphological changes in experimental cardiomyopathy dynamics was established. The scientific data concerning cardiac linear-weight and pathomorphological characteristics in doxorubicin-induced cardiomyopathy were clarified. It was established that the registered changes were typical for acute inflammation. The brain macro- and microelement content changes were characteristic for cardiac insufficiency which developed on the doxorubicin-induced cardiomyopathy background. Behavioral changes characteristic for both anxiety- and depressive-like states were shown in the cardiomyopathy dynamics. Gradual memory impairment was shown to have occurred due to the rats' brain cognitive function major components suppression. Cognitive deficiency and behavioural disturbances in conditions of experimental cardiomyopathy were established to have the same pathogenetic pathways which are based on the neurons' irreversible death.

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